关键词: 癌因性疲乏, CT26结直肠癌, 参芪十一味颗粒

Abstract: Objective　To investigate the effect of Shenqi Shiyiwei Granules (SQS) on cancer-related fatigue (CRF) in CT26 colorectal cancer mice.Methods　Thirty BALB/c mice were randomly divided into a blank group, model group, and SQS group [1.56 g/(kg·d) ],10 mice per group. Except for the blank group, the other two groups were subcutaneously inoculated with CT26 cells in the right hind limb to establish a tumor model. After successful modeling, the treatment group received SQS by gavage for three weeks. Body weight and tumor volume were monitored weekly. Exercise endurance and spontaneous activity were assessed using the forced swimming test and open field test. Liver and gastrocnemius glycogen content, serum urea nitrogen (BUN), lactate (LA) levels, and lactate dehydrogenase (LDH) activity were measured by colorimetric assays. Complete blood counts were analyzed by using an automated hematology analyzer. Spleen and tumor weights were recorded. Pathological changes in gastrocnemius muscle and epididymal adipose tissue were observed by HE staining.Results　Compared with the model group, mice in the SQS group showed significantly increased body weight, prolonged load bearing swimming time, and increased total distance traveled in the open field test, while tumor volume and weight were significantly reduced, the differences were statistically significant (P<0.05). Liver and gastrocnemius glycogen levels were higher, while serum BUN, LA, and LDH were significantly lower (P<0.05). Blood parameters, including red blood cells, hemoglobin, platelet count and white blood cells, were significantly improved, and the differences were statistically significant (P<0.05). Histopathological analysis revealed attenuated gastrocnemius muscle atrophy and enlarged epididymal adipocytes in the SQS group. Conclusion　SQS alleviates CRF by improving energy metabolism, reducing tissue damage, and regulating hematological parameters.

Key words: cancer-related fatigue, CT26 colorectal cancer, Shenqi Shiyiwei Granules